Results
| PMID | 21848410 |
| Gene Name | LEP |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 86 |
| Population details | 86 (58 women with endometriosis and 28 women undergoing tubal ligation) |
| Sex | Female |
| Associated genes | Leptin, IL-8 |
| Other associated phenotypes |
Endometriosis |
|
Gynecol Endocrinol. 2012 Mar;28(3):224-7. doi: 10.3109/09513590.2011.593664. Epub Malhotra, Neena| Karmakar, Debjyoti| Tripathi, Vishwas| Luthra, Kalpana| Kumar, Sunesh Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India. neenamaltra83@yahoo.com UNLABELLED: Pelvic endometriosis is a chronic inflammatory disease with an immunological background. Yet there is paucity of contemporary research exploring both the angiogenic cytokines, leptin and IL-8 for a possible role in its pathophysiology. OBJECTIVE: To compare levels of both leptin and IL-8 in peritoneal fluid (PF) in women with endometriosis vs. fertile controls and correlate with disease stage, type and symptoms. MATERIALS AND METHODS: PF from 58 women with endometriosis and 28 women undergoing tubal ligation was collected at laparoscopy and leptin and IL-8 levels were measured using ELISA. Results showed significantly higher levels of both cytokines in women with endometriosis. Significantly higher leptin and IL-8 levels were demonstrated in patients with early peritoneal (ASRM stage I and II) and advancing disease (ASRM stage III and IV), respectively. Levels of leptin/IL-8 were significantly lower in patients with endometrioma (4.8 ng/mL/32 pg/mL) vs. implants (13.0 ng/mL/68 pg/mL). There was no correlation of infertility or chronic pelvic pain with these levels. CONCLUSION: Both leptin and IL-8 levels are raised in PF of women with endometriosis reflecting inflammation and dysregulated immunomodulation. Higher levels of leptin were seen in early stages; IL-8 seems to stimulate the disease in a dose-dependent manner. Mesh Terms: Adult| Ascitic Fluid/*chemistry| Case-Control Studies| Endometriosis/complications/*metabolism/*pathology| Female| Humans| Infertility, Female/etiology/metabolism| Interleukin-8/*analysis| Leptin/*analysis| Ovarian Diseases/metabolism/pathology| |
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